Insulinotropic action of a-D-glucose pentaacetate: functional aspects
نویسندگان
چکیده
WILLY J. MALAISSE, CARMEN SÁNCHEZ-SOTO, M. ELENA LARRIETA, MARCIA HIRIART, HASSAN JIJAKLI, CONCEPCIÓN VIÑAMBRES, MARÍA L. VILLANUEVA-PEÑACARRILLO, ISABEL VALVERDE, OLE KIRK, MARCEL M. KADIATA, AND ABDULLAH SENER Laboratory of Experimental Medicine, Brussels Free University, B-1070 Brussels, Belgium; Department of Biophysics, Institute of Cellular Physiology, Universidad Nacional Autónoma de México, Mexico City, DF-04510 Mexico City, Mexico; Fundación Jiménez Dı́az, 28040 Madrid, Spain; and Novo Nordisk, DK-2880 Bagsvaerd, Denmark
منابع مشابه
Insulinotropic action of α-d-glucose pentaacetate: functional aspects.
The functional determinants of the insulinotropic action of α-d-glucose pentaacetate were investigated in rat pancreatic islets. The ester mimicked the effect of nutrient secretagogues by recruiting individual B cells into an active secretory state, stimulating proinsulin biosynthesis, inhibiting86Rb outflow, and augmenting45Ca efflux from prelabeled islets. The secretory response to the ester ...
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The metabolism of β-l-glucose pentaacetate and its interference with the catabolism ofl-[U-14C]glutamine, [U-14C]palmitate,d-[U-14C]glucose, andd-[5-3H]glucose were examined in rat pancreatic islets. Likewise, attention was paid to the effects of this ester on the biosynthesis of islet peptides, the release of insulin from incubated or perifused islets, the functional behavior of individual B c...
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Isolated perfused rat pancreases were exposed, in the presence of 10.0 mMl-leucine, to either α-d-glucose pentaacetate, β-l-glucose pentaacetate, or unesterified d-glucose, all tested at a 1.7 mM concentration. The pentaacetate ester of α-d-glucose and, to a lesser extent, that of β-l-glucose stimulated both insulin and somatostatin release, whereas unesterifiedd-glucose failed to do so. In the...
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WILLY J. MALAISSE,1 LEONARD C. BEST,2 ANDRÉ HERCHUELZ,3 MARCIA HIRIART,4 HASSAN JIJAKLI,1 MARCEL M. KADIATA,1 ELENA LARRIETA-CARASCO,4 AOUATIF LAGHMICH,1 KARIM LOUCHAMI,1 DANY MERCAN,1 ELIZABETH OLIVARES,1 CARMEN SÀNCHEZ-SOTO,4 OLIVIER SCRUEL,1 ABDULLAH SENER,1 ISABEL VALVERDE,5 MARÍA L. VILLANUEVA-PEÑACARRILLO,5 CONCEPCIÓN VIÑAMBRES,5 AND WALTER S. ZAWALICH6 Laboratories of 1Experimental Medic...
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